The Athlete

Phendimetrazine (Bontril, Melfiat, Plegine)

Phendimetrazine is an anorectic drug in a similar class as amphetamines (speed). It stimulates the central nervous system, causing rapid heartbeat and an increase in blood pressure. This drug should only be taken for a short time by those who are extremely obese, and only under strict supervision of your doctor.

This drug is widely available over the internet, but I would strongly caution anyone taking it without a doctor's recommendation. The long and short-term side effects can be extremely damaging. The risk factors must be carefully weighed before this drug is prescribed.

Side Effects

Cardiovascular: Palpitation (a strong heartbeat that you can feel), tachycardia (very rapid heartbeat), elevation of blood pressure.

Central Nervous System: overstimulation, restlessness, dizziness, insomnia (sleeplessness), tremor (shaking), headache, psychotic state, agitation (excessive restlessness), flushing, sweating, blurring of vision.

Gastrointestinal: Dryness of the mouth, diarrhea, constipation, nausea, stomach pain.

Genitourinary: Urinary frequency, dysuria (painful urination), changes in libido - this drug acts differently with everyone. Some find their sexual desire is increased tremendously, while others lose all desire.

Abuse and Dependence

Phendimetrazine is classified as a Schedule III controlled substance. This means it has a high potential for abuse and addiction. Phendimetrazine is related chemically and pharmacologically to the amphetamines. Amphetamines and related stimulant drugs have been extensively abused and many are now illegal.

Abuse of amphetamines and related drugs may be associated with intense psychological dependence and severe social dysfunction. There are, reports of patients who have increased the dosage to many times that recommended.

This drug must be used short-term only because long-term use can lead to psychosis, which is often clinically indistinguishable from schizophrenia.

Stopping the drug abruptly after high dosage administration, results in extreme fatigue and mental depression, as well as changes in sleep.

Tolerance

Tolerance is the body's ability to adjust to the drug and to need higher doses to achieve the same effect. Tolerance to the anorectic effect usually develops within a few weeks. When this occurs the recommended dose should not be exceeded in an attempt to increase the effect rather, the drug should be discontinued.

Precautions

Phendimetrazine should not be taken if:
* You have even mild hypertension (high blood pressure)
* You have coronary artery disease
* You have arteriosclerosis (hardening of the arteries)
* You have asthma or any respiratory problems
* You have an allergy or sensitivity to aspirin
* You have glaucoma
* You have hyperthyroidism (over active thyroid)
* You are taking any other stimulants
* You have a history of drug abuse
* You are normally a nervous or easily agitated person

Overdose

Acute overdosage may manifest itself by the following signs and symptoms: unusual restlessness, confusion, belligerence, hallucinations and panic states. Fatigue and depression usually follow the central nervous system stimulation. Cardiovascular effects include arrhythmias, hypertension (high blood pressure), or hypotension (low blood pressure) and circulatory (blood vessels) collapse. Gastrointestinal symptoms include nausea, vomiting, diarrhea and abdominal cramps. Poisoning may result in convulsions, coma and death

Pregnancy

Safe use in pregnancy has not been established. Until more information is available, women who are or may become pregnant unless, in the opinion of the physician, the potential benefits outweigh the possible hazards should not take phendimetrazine.

Usage in Children

Children under 12 should not take Phendimetrazine.

Recommended Dosage

One tablet (35mg) twice a day or three times a day taken one hour before meals. Dosage should be individualized to obtain an adequate response with the lowest effective dosage. In some cases 1/2 tablet (17.5 mg) per dose may be adequate. Dosage should not exceed 2 tablets three times a day. (6 tablets per day)

When properly used phendimetrazine can help the grossly obese lose weight, however it is a potent drug and shouldn't be used if you just have a few pounds to lose. As with all prescription weight loss drugs, have your doctor monitor your progress and should you experience any problems contact your doctor and stop the drug.

Fat-absorption inhibitors such as Xenical are seen to be less dangerous with milder side effects than the appetite supressants. They work by preventing your body from breaking down and absorbing fat eaten with your meals. This unabsorbed fat is eliminated in bowel movements. As with all medications, there are side effects but usually retsricted to gas discharges and bowel movements.

Information for the informed athlete:

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